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How do different synaptic and circuit properties define context-dependent, value based decisions?
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We use optogenetics, two photon microscopy and electrophysiology in vitro to investigate the detailed mechanisms of synaptic connections and how they function. We are currently focussed on the hippocampus and its connections with nucleus accumbens, amygdala and prefrontal cortex.
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We combine our in vitro work with transgenics, viral expression and whole-brain anatomy to link synaptic mechanisms with the role they play in circuit function.
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We use state of the art imaging and physiology techniques in freely behaving animals to allow a direct analysis of the role of the synaptic and circuit mechanisms we are investigating in decision making behaviour.
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